Permeation Study of Vitamin E Emulgels Using Carrageenan a Marine Biota Products as Gelling Agents
DOI:
https://doi.org/10.38035/ijam.v2i2.326Keywords:
Carrageenan, Vitamin E, HPMC, Permeation Test, Franz Diffusion CellAbstract
Carrageenan as one of marine biota products is widely used in various industries such as food, cosmetics, pharmaceuticals, printing, and textile. Application and use of carrageenan in the manufacture of gels and other gel products is still very limited especially for cosmeceutical products. Caraageenan has the ability to form gels in a thermo-reversible waymaking it widely used as a gelling agent, thickener, stabilizer and additional permeation enhancement. Thereby this study aims to conduct how permeation study of Vitamin E an anti-oxidant in emulgels preparations using Carrageenan as gelling agents compare to another gelling agents (HPMC). In vitro permeation tests by Franz Diffusion Cell showed better result for emulgels Carrageenan than HPMC. The cumulative penetrated amounts of Vitamin E emulgels with Carrageenan was 5262.64±49.37 µg/cm2 while HPMC 4453.90±49.37, Fluks values for emulgels Carrageenan and HPMC was 29.24±0.27 and 24.75±0.27 respectively.
References
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Janki Patel, Jui Trivedi, DR. Sunita Chudhary. Formulation and Evaluation Of Diacrein Emulgel For Psoriatic Arthrities. IJPRBS. 2014; 3(2): 625-638.
V. Naga Sravan Kumar Varma et al. Calcipotriol delivery into the skin as emulgel for effective permeation. Saudi Pharm.J. 2014; 22: 591-599.
Rowe, RC., Sheskey, PJ.,Owen, SC. 2006. Handbook of Pharmaceiticals Excipient. 5th ed. Washington Pharmaceutical Press and American Pharmacist Association. P.441-444.
Dignesh, M., Ashish, D., Dinesh, R., 2012. Formulation design & development of piroxicam emulgel. Int. J. Pharm. Tec. Res. 4 (3), 1332-1344.
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Distantina S, Wiratni, Fahrurrozi M, Rochmadi. Carrageenan properties extracted from Euchema cotonii, Indonesia. World Academy of Science, Engineering and Technology. 2011; 54: 738-742.
Campo VL, Kawano, D.F, da Silva Jr, D.B, Carvalho, I. Carrageenan: biological properties. Chemical modifications and structural analysis –a review. Carbohydrate Polymers. 2009; 77:167-180.
Valenta C, Schultz K. Influence of Carrageenan on The Rheology and Skin Permeation of Microemulsion Formulations. Journal of Controlled Release. 2004; 95:257-265.
Adrianus O W Kayaa, A. S. The Effect of Gelling Agent Concentration on the Characteristic of Gel Produced From the Mixture of Semi-refined Carrageenan and Glukomannan . International Journal of Sciences: Basic and Applied Research (IJSBAR), 2015; 20 (1): 313-324 .
Rowe, RC., Sheskey, PJ.,Owen, SC. Handbook of Pharmaceiticals Excipient. 6 ed. Washington Pharmaceutical Press and America Pharmacist Association. 2009. p.17-598.
Asep Bayu, M. F. Macroalgae-derived rare sugars; Applications and catalytic synthesis. Carbon Resources Conversion, 2021; 4:150-163.
Radhakrishman AK, Mahallagam D, Selvaduray KR, Nesaretnam K. Supplementation with Natural Forms of Vitamin E Augments Antigen-Spesific TH 1-Type immune Respons to Tetanus Toxoid. Bio Med Research International. 2013; Volume 2013.
Bauman L. Antioxidants.Weisberg E .ed. 2002. Cosmetic dermatology principles and practice. New York: Mc Graw Hill. 2002; 105-16.
Pinnell SR. Cutaneous photo damage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol, 2003; 48(1):1-12
Lalita A, Aryani S, Suyatna FD. Peranan vitamin E topikal sebagai anti oksidan dalam dermatologi. MDVI, 2003 :28(3):164-72.
Baibhav, Joshi.,Gurprect, Singh., et.al.. 2011. Emulgel : A Comprehensive Review on The Recent Advances in Topical Drug Delivery. Int. Research J.of Pharm., 2 (11): 66-70
Santos LL, Swofford NJ, Santiago BG. In Vitro Permeation Test (IVPT) for Pharmacokinetic Assessment of Topical Dermatological Formulations. Curr Protoc Pharmacol. 2020 Dec;91(1):e79. doi: 10.1002/cpph.79. PMID: 32991075.
Janki Patel, Jui Trivedi, DR. Sunita Chudhary. Formulation and Evaluation Of Diacrein Emulgel For Psoriatic Arthrities. IJPRBS. 2014; 3(2): 625-638.
V. Naga Sravan Kumar Varma et al. Calcipotriol delivery into the skin as emulgel for effective permeation. Saudi Pharm.J. 2014; 22: 591-599.
Rowe, RC., Sheskey, PJ.,Owen, SC. 2006. Handbook of Pharmaceiticals Excipient. 5th ed. Washington Pharmaceutical Press and American Pharmacist Association. P.441-444.
Dignesh, M., Ashish, D., Dinesh, R., 2012. Formulation design & development of piroxicam emulgel. Int. J. Pharm. Tec. Res. 4 (3), 1332-1344.
Kumar, Harikesh & Maurya, Harikesh. (2018). AN OVERVIEW ON ADVANCE VESICLES FORMULATION AS A DRUG CARRIER FOR N.D.D.S. ejbps, 2018, Volume 5, Issue 2 292-303
Naibaho, D.H., Yamkan, V,Y., Weni, Wiyono.2013. Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocinum sanchum L.) pada Kulit Punggung Kelinci yang dibuat Infeksi Staphylococcus aureus, Jurnal ilmiah Farmasi – UNSRAT. 2013; 2(02):
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Published
2023-08-30
How to Cite
Rosmiati, M. . (2023). Permeation Study of Vitamin E Emulgels Using Carrageenan a Marine Biota Products as Gelling Agents. International Journal of Advanced Multidisciplinary, 2(2), 466–474. https://doi.org/10.38035/ijam.v2i2.326
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