Efektivitas Radix Astragali dalam Menurunkan Kadar Gula Darah pada Penderita Dibetes Mellitus
DOI:
https://doi.org/10.38035/jim.v4i5.1499Keywords:
diabetes, herbal, insulin, radix astragali, terapi komplementerAbstract
Diabetes mellitus adalah penyakit metabolik salah satu tandanya adalah peningkatan kadar glukosa darah akibat gangguan sekresi insulin pada tubuh. Radix astragali telah lama digunakan sebagai herbal yang berpotensi meningkatkan metabolisme glukosa dan sensitivitas insulin. Tujuan penelitian untuk mengetahui efektivitas Radix astragali untuk membantu menurunkan kadar gula darah pada penderita diabetes mellitus. Metode penelitian menggunakan desain studi kasus eksperimental dengan 12 subjek yang dipilih secara purposive dan dibagi menjadi kelompok kontrol dan perlakuan. Kelompok perlakuan diberi Herbal Radix Astragali sebanyak 3 gram setiap pagi selama 21 hari, sedangkan kelompok kontrol tidak menerima perlakuan. Variabel yang diukur adalah gula darah puasa, HbA1c, dan berat badan. Analisis yang digunakan adalah uji T. Hasil penelitian menunjukkan bahwa terdapat penurunan signifikan kadar gula darah puasa pada kelompok perlakuan (p=0,029), sedangkan kelompok kontrol tidak mengalami perubahan signifikan (p=0,798). Nilai HbA1c juga menurun signifikan pada kelompok perlakuan (p=0,049), tetapi tidak pada kelompok kontrol (p=0,234). Penurunan berat badan pada kelompok perlakuan tidak signifikan secara statistik, meskipun terjadi selisih mean sebesar 0,5 kg. Kesimpulan penelitian ini menunjukkan bahwa pemberian Radix Astragali selama 21 hari efektif menurunkan kadar gula darah puasa dan HbA1c pada penderita diabetes mellitus, sehingga dapat dipertimbangkan sebagai terapi komplementer dalam pengelolaan diabetes mellitus tipe 2.
References
Agustiningsih, L. D., & Wijaya, A. (n.d.). Deteksi Dini Nefropati Diabetik Pada Penderita Diabetes Mellitus Tipe 2.
Andreani, F. V., Belladonna, M., & Hendrianingtyas, M. (2018). Hubungan Antara Gula Darah Sewaktu Dan Puasa Dengan Perubahan Skor Nihss Pada Stroke Iskemik Akut. Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal), 7(1), Article 1.
Chen, X., Wang, H., Jiang, M., Zhao, J., Fan, C., Wang, Y., & Peng, W. (2018). Huangqi (astragalus) decoction ameliorates diabetic nephropathy via IRS1-PI3K-GLUT signaling pathway. American Journal of Translational Research, 10(8), 2491–2501.
Collins, K. A., Kraus, W. E., Rogers, R. J., Hauser, E. R., Lang, W., Jiang, R., Schelbert, E. B., Huffman, K. M., & Jakicic, J. M. (2023). Effect of behavioral weight-loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial. Obesity, 31(2), 338–349. https://doi.org/10.1002/oby.23618
Geer, E. B., & Shen, W. (2009). Gender Differences in Insulin Resistance, Body Composition, and Energy Balance. Gender Medicine, 6(Suppl 1), 60–75. https://doi.org/10.1016/j.genm.2009.02.002
Hao, M., Guan, Z., Gao, Y., Xing, J., Zhou, X., Wang, C., Xu, J., & Li, W. (2020). Huang-Qi San ameliorates hyperlipidemia with obesity rats via activating brown adipocytes and converting white adipocytes into brown-like adipocytes. Phytomedicine?: International Journal of Phytotherapy and Phytopharmacology, 78, 153292. https://doi.org/10.1016/j.phymed.2020.153292
Huang, Y.-C., Tsay, H.-J., Lu, M.-K., Lin, C.-H., Yeh, C.-W., Liu, H.-K., & Shiao, Y.-J. (2017). Astragalus membranaceus-Polysaccharides Ameliorates Obesity, Hepatic Steatosis, Neuroinflammation and Cognition Impairment without Affecting Amyloid Deposition in Metabolically Stressed APPswe/PS1dE9 Mice. International Journal of Molecular Sciences, 18(12), Article 12. https://doi.org/10.3390/ijms18122746
Kong, D.-X., Xiao, Y., Zhang, Z.-X., & Liu, Y.-B. (2020). Study on the Correlation between Metabolism, Insulin Sensitivity and progressive weight loss change in Type-2 Diabetes. Pakistan Journal of Medical Sciences, 36(7), 1523–1528. https://doi.org/10.12669/pjms.36.7.3027
Li, Y., Wang, C., Jin, Y., Chen, H., Cao, M., Li, W., Luo, H., & Wu, Z. (2020). Huang-Qi San improves glucose and lipid metabolism and exerts protective effects against hepatic steatosis in high fat diet-fed rats. Biomedicine & Pharmacotherapy, 126, 109734. https://doi.org/10.1016/j.biopha.2019.109734
Liu, S., Wang, L., Zhang, Z., Leng, Y., Yang, Y., Fu, X., Xie, H., Gao, H., & Xie, C. (2024). The potential of astragalus polysaccharide for treating diabetes and its action mechanism. Frontiers in Pharmacology, 15, 1339406. https://doi.org/10.3389/fphar.2024.1339406
Liu, Y., Sun, M., Yao, H., Liu, Y., & Gao, R. (2017). Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017. Evidence-Based Complementary and Alternative Medicine: eCAM, 2017, 8943059. https://doi.org/10.1155/2017/8943059
Tandra, H. (2017). Segala Sesuatu yang Harus Anda Ketahui Tentang Diabetes. Gramedia Pustaka Utama.
Willcox, M. L., Elugbaju, C., Al-Anbaki, M., Lown, M., & Graz, B. (2021). Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.777561
Yusuf -, B. (2023). Literatur Review: Gula Darah Puasa Pada Penyakit Diabetes Melitus: Indonesia. Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ), 6(1), Article 1. https://doi.org/10.35799/pmj.v6i1.47617
Zheng, Y., Ren, W., Zhang, L., Zhang, Y., Liu, D., & Liu, Y. (2020). A Review of the Pharmacological Action of Astragalus Polysaccharide. Frontiers in Pharmacology, 11. https://doi.org/10.3389/fphar.2020.00349
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