Hubungan Gambaran Histopatologi Sumsum Tulang dengan Hasil Pemeriksaan Hb, Leukosit dan Trombosit pada Pasien Leukemia
DOI:
https://doi.org/10.38035/jim.v5i1.1804Keywords:
Leukemia, Histopatologi Sumsum Tulang, Hb, Leukosit, TrombositAbstract
Leukemia merupakan keganasan hematologi akibat proliferasi abnormal sel induk hematopoietik di sumsum tulang yang menyebabkan gangguan hematopoiesis dan perubahan kadar Hb, leukosit, serta trombosit. Secara global, leukemia menyumbang 2,5% insiden kanker baru, sementara di Indonesia insidensinya mencapai 3,4% dari seluruh keganasan. Pemeriksaan histopatologi sumsum tulang merupakan standar emas diagnosis, namun pemeriksaan darah lengkap lebih mudah tersedia secara luas. Tujuan penelitian ini adalah untuk menilai hubungan antara gambaran histopatologi sumsum tulang yang meliputi persentase sel blast, selularitas, dan derajat fibrosis, dengan hasil pemeriksaan darah lengkap yaitu kadar Hb, leukosit, dan trombosit pada pasien leukemia. Sampel berjumlah 100 orang menggunakan teknik consecutive sampling. Analisis hubungan menggunakan uji Pearson Chi-Square atau Fisher’s Exact. Berdasarkan hasil penelitian dapat disimpulkan tidak terdapat hubungan bermakna (p > 0.05) antara gambaran histopatologi sumsum tulang dengan parameter darah lengkap.
References
Alwi, I., Setiati, S., Syam, A. F., Sudoyo, A. W., Kolopaking, M. S., & Nasution, S. A. (Eds.). (2024). Buku Ajar Ilmu Penyakit Dalam (7th ed., Vol. 2). Interna Publishing.
Arber, D. A., Orazi, A., Hasserjian, R. P., Borowitz, M. J., Calvo, K. R., Kvasnicka, H.-M., Wang, S. A., Bagg, A., Barbui, T., Branford, S., Bueso-Ramos, C. E., Cortes, J. E., Dal Cin, P., DiNardo, C. D., Dombret, H., Duncavage, E. J., Ebert, B. L., Estey, E. H., Facchetti, F., … Tefferi, A. (2022). International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood, 140(11), 1200–1228. https://doi.org/10.1182/blood.2022015850
Aruah, S. C. (2025). A prospective study of anemia in cancer patients undergoing chemoradiation using serial hemoglobin measurement in North Central region, Nigeria. Clinical Cancer Research, 31(2). https://doi.org/10.1158/1557-3265.
de Haas, V., Ismaila, N., Advani, A., Arber, D. A., Dabney, R. S., Patel-Donelly, D., Kitlas, E., Pieters, R., Pui, C.-H., Sweet, K., & Zhang, L. (2019). Initial Diagnostic Work-Up of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists and American Society of Hematology Guideline. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 37(3), 239–253. https://doi.org/10.1200/JCO.18.01468
Ferlay, J., Ervik, M., Lam, F., Laversanne, M., Colombet, M., Mery, L., Piñeros, M., Znaor, A., Soerjomataram, I., & Bray, F. (2024). Global Cancer Observatory: Cancer Today. International Agency for Research on Cancer.
Gbenjo, J. T. C., McCrary, G. L. M., & Wilson, S. E. (2023). Leukemia: What Primary Care Physicians Need to Know. American Family Physician, 107(4), 397–405.
Gökbuget, N., Boissel, N., Chiaretti, S., Dombret, H., Doubek, M., Fielding, A., Foà, R., Giebel, S., Hoelzer, D., Hunault, M., Marks, D. I., Martinelli, G., Ottmann, O., Rijneveld, A., Rousselot, P., Ribera, J., & Bassan, R. (2024). Diagnosis, Prognostic Factors, and Assessment of ALL in Adults: 2024 ELN Recommendations from a European Expert Panel. Blood, 143(19), 1891–1902. https://doi.org/10.1182/blood.2023020794
Huang, J., Chan, S. C., Ngai, C. H., Lok, V., Zhang, L., Lucero-Prisno, D. E., Xu, W., Zheng, Z. J., Elcarte, E., Withers, M., & Wong, M. C. S. (2022). Disease Burden, Risk Factors, and Trends of Leukaemia: A Global Analysis. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.904292
Jain, A. G., Zhang, L., Bennett, J. M., & Komrokji, R. (2022). Myelodysplastic Syndromes with Bone Marrow Fibrosis: An Update. Annals of Laboratory Medicine, 42(3), 299–305. https://doi.org/10.3343/alm.2022.42.3.299
Kaya, A., Erkurt, M. A., Kuku, I., Kaya, E., Berber, I., Sarici, A., Bozdaǧ, Z., Biçim, S., Arslan, S., & Yagin, F. H. (2024). Relationship Between Reticular Fibrosis With Platelet Surface Markers (CD41A, CD42A, CD42B, CD61) and Prognostic Markers (WBC, PLT) in Acute Promyelocytic Leukemia. Acta Haematologica Polonica, 55(5), 252–259. https://doi.org/10.5603/ahp.99939
Li, J. F., Cheng, W. Y., Lin, X. J., Wen, L. J., Wang, K., Zhu, Y. M., Zhu, H. M., Chen, X. J., Zhang, Y. L., Yin, W., Zhang, J. N., Yi, X., Zhang, F., Weng, X. Q., Wang, S. Y., Jiang, L., Wu, H. Y., Ren, J. Q., Lin, X. J., … Shen, Y. (2024). Aging and Comprehensive Molecular Profiling in Acute Myeloid Leukemia. Proceedings of the National Academy of Sciences of the United States of America, 121(10). https://doi.org/10.1073/pnas.2319366121
Mohamed, S. F., Mulikandathil, Y., Soliman, D. S., Abbas, F., Alshurafa, A., Afana, M., Ellahie, A. Y., Mudawi, D. S., El Omri, H., Gameil, A., Abuasab, T., Haddad, F., Singh, K., Kassem, N., & Cherif, H. (2022). Clinicopathologic Characteristics and Outcome of Acute Myeloid Leukemia with (AML) with Core Binding Factor (CBF) Rearrangements: A Retrospective Study. Blood, 140, 11651–11652. https://doi.org/10.1182/blood-2022-167176
Munir, A. H., & Khan, M. I. (2019). Pattern of Basic Hematological Parameters in Acute and Chronic Leukemias. J. Med. Sci, 27(2).
Prashanti, N. A. P., & Rena, N. M. R. A. (2020). Karakteristik Penderita Leukemia Akut yang Dirawat di RSUP Sanglah Denpasar Tahun 2014-2015. Jurnal Medika Udayana, 9.
Rahadiyanto, K. Y., Liana, P., & Indriani, B. (2014). Pola Gambaran Darah Tepi pada Penderita Leukimia di Laboratorium Klinik RSUP Dr. Mohammad Hoesin Palembang. Majalah Kedokteran Sriwijaya, 46(4), 259–265.
Ruminski, P. G., Rettig, M. P., & DiPersio, J. F. (2024). Development of VLA4 and CXCR4 Antagonists for the Mobilization of Hematopoietic Stem and Progenitor Cells. Biomolecules, 14(8). https://doi.org/10.3390/biom14081003
Schmidt, J.-A., Hornhardt, S., Erdmann, F., Sánchez-García, I., Fischer, U., Schüz, J., & Ziegelberger, G. (2021). Risk Factors for Childhood Leukemia: Radiation and Beyond. Frontiers in Public Health, 9. https://doi.org/10.3389/fpubh.2021.805757
Shallis, R. M., Wang, R., Davidoff, A., Ma, X., & Zeidan, A. M. (2019). Epidemiology of Acute Myeloid Leukemia: Recent Progress and Enduring Challenges. Blood Reviews, 36, 70–87. https://doi.org/10.1016/j.blre.2019.04.005
Singh, D., & Agarwal, R. (2025). Correlation Between Hematological Parameters and Disease Severity in Acute Leukemia Patients. International Journal of Medicine and Public Health, 15. https://doi.org/10.70034/ijmedph.2025.1.79
Tebbi, C. K. (2021). Etiology of Acute Leukemia: A Review. Cancers, 13(9), 2256. https://doi.org/10.3390/cancers13092256
Weiss, G., Ganz, T., & Goodnough, L. T. (2019). Anemia of Inflammation. Blood, 133(1), 40–50. https://doi.org/10.1182/blood-2018-06-856500
Wong, J., Jackson, R., Chen, L., Song, J., Pillai, R., Afkhami, M., Danilova, O., Aoun, P., Gaal, K. K., & Kim, Y. (2024). Determination of Age-dependent Bone Marrow Normocellularity. American Journal of Clinical Pathology, 161(2), 170–176. https://doi.org/10.1093/ajcp/aqad129
Zhang, X., Wang, F., Yu, J., & Jiang, Z. (2022). Significance of Bone Marrow Fibrosis in Acute Myeloid Leukemia for Survival in the Real-World. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.971082
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