A Chronic Hemophilia Patient With Manifestations of Spontaneous Penile Bleeding and Multiarthropathy
DOI:
https://doi.org/10.38035/ijphs.v3i1.755Keywords:
Hemophilia A, Factor VIII Deficiency, Bleeding Disorder, Multiarthropathy, Penile BleedingAbstract
Hemophilia A is a hereditary bleeding disorder characterized by Factor VIII deficiency, with varying severity levels. This report presents a 27-year-old male patient with moderate Hemophilia A who experienced spontaneous penile bleeding and a history of multiarthropathy. The patient reported recurrent bleeding episodes since childhood and received Factor VIII therapy, resulting in significant symptom relief. This case highlights the importance of individualized management in chronic hemophilia, focusing on preventive measures to mitigate future bleeding episodes and comorbidities, thereby improving quality of life and life expectancy. Case report : A 27-year-old male patient presented with spontaneous penile bleeding triggered by minor trauma and associated with moderate Factor VIII deficiency (1%). Past medical history included recurrent joint and gastrointestinal bleeding episodes. The patient responded positively to Factor VIII therapy and packed red cell transfusions, with symptom resolution after 10 days of hospitalization. Family pedigree analysis and coagulation studies confirmed the diagnosis of moderate Hemophilia A. Discussion : Hemophilia A patients face lifelong bleeding risks, with multiarthropathy as a common complication. Factor VIII levels closely correlate with disease severity and bleeding manifestations. Preventive therapy, including Factor VIII administration, is crucial for minimizing complications. Additionally, managing viral infection risks is essential due to associated sexual behavior in certain demographics. Regular screening and patient education play pivotal roles in comprehensive care. Conclusion : This case underscores the significance of proactive management in moderate Hemophilia A, emphasizing tailored therapy and preventive strategies. Ensuring adequate access to clotting factor concentrates and addressing comorbidities can significantly enhance the quality of life and prognosis for chronic hemophilia patients.
References
Dolan, The Challenge Of An Ageing Haemophilic Population, Haemophilia J 2010 ; 16 : 11 - 16
Oldenburg, G. Dolan, and G. Lemm. Haemophilia Care Then, Now And In The Future. Haemophilia J 2009 ; 15 : 2 – 7
Konkle, C. Kessler, L. Aledort. Emerging Clinical Concerns In The Ageing Haemophilia Patient. Haemophilia J 2009 ; 6 : 1197 – 1209
Plug, I. Van Der Bom, JG. & Peters, M. Mortality And Causes Of Death In Patients With Haemophilia, 1992-2001: a prospective cohort study. J Thromb Haemost 2006 ; 4 : 510- 516
Chorba, TL. Holman, RC. Clarke, MJ. Evatt, BL. Effects of HIV Infection On Age And Cause Of Death For Persons With Haemophilia A in the United States. Am J Hematol 2001 ; 66 : 229-240
Tagliaferri, A. Rivolta, GF. Ioro, A. Mortality And Causes Of Death In Italian Persons With Haemophilia. Haemophilia J 2010 ; 16 : 437-466
Messina LM,MD, Pak LK,MD, Tierney LM,Jr,MD, Blood Vessels & Lymphatics. In : Tierney LM,Jr,MD, McPhee SJ, Papadakis MA. 2004 Lange Current Medical Diagnosis & Treatment, 43rd ed. New York : Lange Medical Books/McGraw Hill ; 2004 : 505-7
Lozier JN, Kessler CM. Clinical Aspects and Therapy of Hemophilia. In : Hoffman R, Benzej, Shantil SJ, Furie B, Cohen HJ, SilberstainLE, Mc Glave P, (eds). Hematology. Basic Principles and Practice 3rd ed. New York : Churchill Living stone 2000 ; 884-901
Mejia-Carvajal, C. Czapek, EE. and Valentino, LA. Life Expectancy In Mophilia Outcome. Journal of Thrombosis and Haemostasis 2006 ; 4 : 507-509.
Franchini, M. Lippi, G. Montagnana, M. Targher, G. Zaffanello, M. Salvagno, GL. Rivolata, GF. Perna, C.D. and Tagliaferri, A. Haemophilia And Cancer: A New Challenge For Hemophilia Centers . Cancer Treatment Reviews 2009 ; 35 : 374-377
Dolan, G. The Challenge Of An Ageing Hemophilia Population. Haemophilia J 2010 ; 16 : 11-16.
Kulkarni, R. Soucie, JM. and Evatt, B. Hemophilia Surveillance System Project Investigators. Disease Among Males With Haemophilia. Haemophilia J 2006 ; 9 : 703-710.
Nilsson, IM. Berntorp, E. Lofqvist, T. and Pettrsson, H. Twenty-Five Years‚ Experience Of Prophylactic In Severe Haemophilia A And B. J Intern Med 1992 ; 232 : 25-32.
Siboni, SM. Mannucci, PM. Gringeri, A. Health Status And Quality Of Life Of Elderly Persons With Severe -Hemophilia Born Before The Advent Of Modern Replacement Therapy. J Thromb Haemost 2009 ; 7 : 780-786
Wallny, TA. S. D. Oldenburg, J. Nicolay, C. Ezziddin, S. Pennekamp, PH. Stoffel-Wagner, B. Kraft, CN. Osteoporosis in haemophilia - an underestimated comorbidity? Haemophilia J 2007 ; 13 : 79-84
Kovacs, CS. Hemophilia, Low Bone Mass, And Osteopenia/Osteoporosis. Transf Apher Sci. Haemophilia J 2008 ; 38 : 1079-1083
Posthouwer, D Makris, M. Progression To End-Stage Liver Disease In Patients With Inherited Bleeding Disorders And Hepatitis C: An International, Multicenter Cohort Study. Blood 2007 ; 9 : 3667-3671
Ragni, MV. Belle, SH. Jaffe, RA. Acquired Immunodeficiency Syndromeassociated Non- Hodgkin’s Lymphomas And Other Malignancies In Patients With Hemophilia. Blood 1993 ; 81 : 1889-1897
Wilde JT, Lee CA, Darby SC. The incidence of lymphoma in the UK haemophilia population between 1978 and 1999. Haemofilia J. 2002 ; 16 : 1803-1807
Darby, SC. Kan, SW. Spooner, RJ. Giangrande, PLF. Hill, FGH. Hay, CRM. Lee, CA. Ludlam, CA. and Williams, M. Mortality Rates, Life Expectancy, And Causes Of Death In People With Hemophilia A Or B In The United Kingdom Who Were Not Infected With HIV. Blood 2007 ; 110 : 815-825
Eckhart, Cl. Menke, LA. van Ommen, CH .Intensive Peri-Operative Use Of Factor VIII And The Arg593cys Mutation Are Risk Factors For Inhibitor Development. J Thromb Haemost 2009 ; 7 : 9228-929.
Salek, ZS, Elezovic. The Need For Speed In The Managenet Of Haemophilia Patients With Inhibitors. Haemophilia J 2011 ; 17 : 95-102
Rivolta, GF. Di Perna, C. Franchini, M. Riccardi, F. Ippolito, L. Lombardi, M. & Tagliaferi, A. Successful Immune Tolerance Induction With Factor VIII/Von Willebrand Factor Concentrate In An Elderly Patient With Severe Haemophilia A And A High Responder Inhibitor. Blood 2010 ; 8 : 66-68.
Bruggemann, LW. Versteeg, HH.; Nieres, TM.. Reitsma, PH.; and Spek, CA. Experimental Melanoma Metastasis In Lungs Of Mice With Congenital Coagulation Disorders. J Cell mol Med 2008 ; 12 : 2622-2627
Mannucci, PM.. Schutgens, REG. Santagostino, E. and Mauser-Bunschoten, EP. How I treat age-related morbidities in elderly persons with hemophilia. Blood 2009 ; 114 : 5256- 5263.
Davies, NM.. Reynolds, JK. Undeberg, MR. Gates, BJ. Ohgami, Y. Vega-Villa, KR. Minimizing risks of NSAIDs: Cardiovascular, Gastrointestinal And Renal. Expert Rev Neurother 2006 ; 11 : 1643- 1655
Downloads
Published
Issue
Section
License
Copyright (c) 2025 I Putu Eka Dharma Putra
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish their manuscripts in this journal agree to the following conditions:
- The copyright on each article belongs to the author(s).
- The author acknowledges that the International Journal of Psycology and Healt Science (IJPHS) has the right to be the first to publish with a Creative Commons Attribution 4.0 International license (Attribution 4.0 International (CC BY 4.0).
- Authors can submit articles separately, arrange for the non-exclusive distribution of manuscripts that have been published in this journal into other versions (e.g., sent to the author's institutional repository, publication into books, etc.), by acknowledging that the manuscript has been published for the first time in the IJPHS.
