Sexual Function and Quality of Life in Cervical Cancer Survivors After Therapy: A Post COVID-19 Updated Scoping Review
DOI:
https://doi.org/10.38035/ijphs.v4i1.2087Keywords:
Cervical Cancer, Sexual Function, Quality of Life, After Therapy, Survivorship, Post-COVID-19Abstract
Cervical cancer survivors frequently experience long-term physical and psychosocial sequelae after therapy, with sexual dysfunction and impaired quality of life (QoL) being among the most significant concerns. The COVID-19 pandemic has further disrupted cancer care, potentially altering survivorship outcomes. Purpose: This scoping review aimed to map and synthesize recent evidence (2022–2025) on sexual function and QoL among cervical cancer survivors after therapy in the post-pandemic context. Methods: A scoping review was conducted following the PRISMA-ScR framework. Articles were identified through PubMed, Scopus, and EBSCOhost: Medline Ultimate using keywords related to sexual function, QoL, cervical cancer, and post-therapy. Eligible studies were observational, published in English, and focused on survivors’ sexual function and QoL after treatment. Twenty studies met the inclusion criteria and were analyzed thematically using a descriptive exploratory approach. Results: A total of 20 articles were analyzed in this review. Majority of studies reported a high prevalence of sexual dysfunction post-therapy, including decreased desire, lubrication problems, dyspareunia, and reduced satisfaction. Although some intervention studies demonstrated improvements, sexual function generally remained impaired. QoL outcomes were more heterogeneous; several studies indicated poor QoL due to treatment-related symptoms (pain, fatigue, urinary and gastrointestinal dysfunction), while others found that more than half of survivors maintained good QoL. Conclusion: Sexual dysfunction remains a pervasive issue among cervical cancer survivors, while QoL outcomes vary depending on treatment modalities, psychosocial support, and coping strategies. A multidisciplinary survivorship approach including medical, psychological, and sexual health support is essential to improve post-therapy well-being in the post-COVID-19 era.
References
American Cancer Society. (2024). American Cancer Society Releases Latest Global Cancer Statistics.
Amo-Antwi, K., Agambire, R., Konney, T. O., Nguah, S. B., Dassah, E. T., Nartey, Y., Appiah-Kubi, A., Tawiah, A., Tannor, E. K., Peprah, A., Ansah, M. B., Sam, D., Akakpo, P. K., Ankobea, F., Djokoto, R. M., Idun, M. Y. K., Opare-Addo, H. S., Opoku, B. K., Odoi, A. T., & Johnston, C. (2022). Health-related quality of life among cervical cancer survivors at a tertiary hospital in Ghana. PLoS ONE, 17(6 June), 1–18. https://doi.org/10.1371/journal.pone.0268831
Carter, J., Huang, H. Q., Monk, B. J., Kim, Y., Kim, M., Stuckey, A., Vicus, D. L., Holman, L. L., Fleury, A. C., Pearson, J. M., Thawani, N., Shahin, M., Lea, J., Robertson, S. E., Warshal, D., Backes, F. J., Feltmat, C., Wilkinson-ryan, I., & Covens, A. (2025). Gynecologic Oncology Evaluation of physical function and quality of life before and after nonradical surgical therapy for stage IA1 and IA2-IB1 cervical cancer ( GOG-0278 ). Gynecologic Oncology, 195, 50–58. https://doi.org/10.1016/j.ygyno.2025.02.023
Corrêa, C. S. L., Leite, I. C. G., Andrade, A. P. S., de Souza Sérgio Ferreira, A., Carvalho, S. M., & Guerra, M. R. (2016). Sexual function of women surviving cervical cancer. Archives of Gynecology and Obstetrics, 293(5), 1053–1063. https://doi.org/10.1007/s00404-015-3857-0
Daga, D., Dana, R., Gaur, P., & Spartacus, R. K. (2017). Sexual Function in Cervical Cancer Survivors after Concurrent Chemoradiotherapy. Middle East Journal of Cancer, 8(July), 151–154.
Dahiya, N., Acharya, A. S., Bachani, D., & Sharma, D. N. (2016). Quality of Life of Patients with Advanced Cervical Cancer before and after Chemo-radiotherapy. Asian Pac J Cancer Prev, 17(7), 3095–3099.
Delican, S., & Güngörmüş, Z. (2024). Sexual Quality of Life and Sexual Problems of Women with Gynecological Cancer: Evaluation According to Treatment Methods and Cancer Types. Sexuality and Disability, 42(1), 3–16. https://doi.org/10.1007/s11195-023-09820-z
Di Donna, M. C., Cucinella, G., Giallombardo, V., Sozzi, G., Bizzarri, N., Scambia, G., Pecorino, B., Scollo, P., Berretta, R., Capozzi, V. A., Laganà, A. S., & Chiantera, V. (2023). Urinary, Gastrointestinal, and Sexual Dysfunctions after Chemotherapy, Radiotherapy, Radical Surgery or Multimodal Treatment in Women with Locally Advanced Cervical Cancer: A Multicenter Retrospective Study. Cancers, 15(24). https://doi.org/10.3390/cancers15245734
El Ghazaly, H., Saad, A., Samy, N., Kamal, K., Medhat, D., & Tawfic, A. (2023). Follow Up of Quality of Life and Sexual Wellbeing in Gynaecological Cancers: a Cross Sectional Study. Ain Shams Medical Journal, 74(1), 111–123. https://doi.org/10.21608/asmj.2023.298215
Facondo, G., Vullo, G., De Sanctis, V., Vitiello, C., Nieddu, L., Alfò, M., Scaringi, C., De Felice, F., Rotondi, M., De Giacomo, F., Ruscito, I., Valeriani, M., & Osti, M. F. (2022). Quality of life and sexual functioning among endometrial cancer patients treated with one week adjuvant high-dose-rate vaginal brachytherapy schedule. Journal of Contemporary Brachytherapy, 14(4), 341–346. https://doi.org/10.5114/jcb.2022.119198
Frumovitz, M., Sun, C. C., Schover, L. R., Munsell, M. F., Jhingran, A., Wharton, J. T., Eifel, P., Bevers, T. B., Levenback, C. F., Gershenson, D. M., & Bodurka, D. C. (2005). Quality of life and sexual functioning in cervical cancer survivors. Journal of Clinical Oncology, 23(30), 7428–7436. https://doi.org/10.1200/JCO.2004.00.3996
Joanna Briggs Institute (JBI). (2022). JBI’s critical appraisal tools. Joanna Briggs Institute.
Khalil, J., Bellefqih, S., Sahli, N., Afif, M., Elkacemi, H., Elmajjaoui, S., Kebdani, T., & Benjaafar, N. (2015). Impact of cervical cancer on quality of life: beyond the short term (Results from a single institution). Gynecologic Oncology Research and Practice, 2(1), 2–7. https://doi.org/10.1186/s40661-015-0011-4
Liberacka-Dwojak, M., Wiłkość-Dębczyńska, M., & Ziółkowski, S. (2023). A Pilot Study of Psychosexual Functioning and Communication in Women Treated for Advanced Stages of Cervical Cancer After the Diagnosis. Sexuality Research and Social Policy, 20(3), 1258–1266. https://doi.org/10.1007/s13178-023-00796-1
Membrilla-Beltran, L., Cardona, D., Camara-Roca, L., Aparicio-Mota, A., Roman, P., & Rueda-Ruzafa, L. (2023). Impact of Cervical Cancer on Quality of Life and Sexuality in Female Survivors. International Journal of Environmental Research and Public Health, 20(4). https://doi.org/10.3390/ijerph20043751
Mishra, N., Singh, N., Sachdeva, M., & Ghatage, P. (2021). Sexual Dysfunction in Cervical Cancer Survivors: A Scoping Review. Women’s Health Reports, 2(1), 594–607. https://doi.org/10.1089/whr.2021.0035
Mohammadi, Z., Maasoumi, R., Vosoughi, N., Eftekhar, T., Soleimani, M., & Montazeri, A. (2022). The effect of the EX-PLISSIT model-based psychosexual counseling on improving sexual function and sexual quality of life in gynecologic cancer survivors: a randomized controlled clinical trial. Supportive Care in Cancer, 30(11), 9117–9126. https://doi.org/10.1007/s00520-022-07332-8
Mvunta, D. H., August, F., Dharsee, N., Mvunta, M. H., Wangwe, P., Ngarina, M., Simba, B. M., & Kidanto, H. (2022). Quality of life among cervical cancer patients following completion of chemoradiotherapy at Ocean Road Cancer Institute (ORCI) in Tanzania. BMC Women’s Health, 22(1), 426. https://doi.org/10.1186/s12905-022-02003-6
Naert, E., Decruyenaere, A., Bultijnck, R., De Jaeghere, E. A., Orije, M. R. P., Salihi, R., Verstraelen, H., Tummers, P., Denys, H. G., & Vandecasteele, K. (2023). Vaginal morbidity, sexual functioning, and health-related quality of life in cervical cancer survivors: a cross-sectional multicenter study (VAMOS). Supportive Care in Cancer, 31(12), 1–11. https://doi.org/10.1007/s00520-023-08155-x
Novackova, M., Pastor, Z., Chmel, R., & Mala, I. (2022). Sexuality and quality of life after nerve-sparing radical hysterectomy for cervical cancer: A prospective study. Taiwanese Journal of Obstetrics and Gynecology, 61(4), 641–645. https://doi.org/10.1016/j.tjog.2021.10.006
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. The BMJ, 372, 1–11. https://doi.org/10.1136/bmj.n71
Pasek, M., Suchocka, L., Osuch-Pęcak, G., Muzykiewicz, K., Iwańska, E., Kaducakowa, H., Goździalska, A., & Goździalska, M. (2021). Longitudinal health-related quality of life study among cervical cancer patients treated with radiotherapy. Journal of Clinical Medicine, 10(2), 1–11. https://doi.org/10.3390/jcm10020226
Peterson, J., Pearce, P. F., Ferguson, L. A., & Langford, C. A. (2017). Understanding scoping reviews: Definition, purpose, and process. Journal of the American Association of Nurse Practitioners, 29(1), 12–16. https://doi.org/10.1002/2327-6924.12380
Pfaendler, K. S., Wenzel, L., Mechanic, M. B., & Penner, K. R. (2015). Cervical cancer survivorship: Long-term quality of life and social support. Clinical Therapeutics, 37(1), 39–48. https://doi.org/10.1016/j.clinthera.2014.11.013
Salim, H. M., Abdelmonem, M. M., & ElSayed, A. M. (2023). Nursing counseling utilizing BETTER model on sexuality, marital satisfaction and quality of life among cervical cancer women. Egyptian Nursing Journal, 20(1), 57–67. https://doi.org/10.4103/enj.enj_54_22
Samaila, A., Biambo, A. A., Usman, N., Aliyu, U. M., Abdullahi, A., & Adibe, M. O. (2023). Health-related quality of life associated with different cervical cancer therapies received by patients in two Nigerian tertiary hospitals. African Health Sciences, 23(3), 261–268. https://doi.org/10.4314/ahs.v23i3.32
Sari, R. I., Ardiyanti, A., & Puspita, N. V. I. (2024). The Relationship between Sexual Function and Quality of Life in Patients. Profesional Health Journal, 7(1), 55–61.
Sorokin, P., Kulikova, S., Nikiforchin, A., & Ulrikh, E. (2024). Impact of Various Treatment Modalities on Long-Term Quality of Life in Cervical Cancer Survivors. Cureus, 16(9). https://doi.org/10.7759/cureus.68642
Stanca, M., Căpîlna, D. M., & Căpîlna, M. E. (2022). Long-Term Survival, Prognostic Factors, and Quality of Life of Patients Undergoing Pelvic Exenteration for Cervical Cancer. Cancers, 14(9). https://doi.org/10.3390/cancers14092346
Stanca, M., Căpîlna, D. M., Trâmbițaș, C., & Căpîlna, M. E. (2022). The Overall Quality of Life and Oncological Outcomes Following Radical Hysterectomy in Cervical Cancer Survivors Results from a Large Long-Term Single-Institution Study. Cancers, 14(2). https://doi.org/10.3390/cancers14020317
Stuopelytė, R., Žukienė, G., Breivienė, R., Rudaitis, V., & Bartkevičienė, D. (2023). Quality of Life in Cervical Cancer Survivors Treated with Concurrent Chemoradiotherapy. Medicina (Lithuania), 59(4). https://doi.org/10.3390/medicina59040777
Suvaal, I., Kirchheiner, K., Nout, R. A., Sturdza, A. E., Van Limbergen, E., Lindegaard, J. C., Putter, H., Jürgenliemk-Schulz, I. M., Chargari, C., Tanderup, K., Pötter, R., Creutzberg, C. L., & ter Kuile, M. M. (2023). Vaginal changes, sexual functioning and distress of women with locally advanced cervical cancer treated in the EMBRACE vaginal morbidity substudy. Gynecologic Oncology, 170, 123–132. https://doi.org/10.1016/j.ygyno.2023.01.005
Tehranian, A., Vahid Dastjerdi, M., Hatamian, S., & Ghahghaei-Nezamabadi, A. (2024). Sexual Function and Quality of Life in Iranian Women With Human Papillomavirus Infection. Journal of Family and Reproductive Health, 18(3), 154–159. https://doi.org/10.18502/jfrh.v18i3.16656
Teshome, R., Yang, I., Woldetsadik, E., Girma, E., Higgins, M., & Wells, J. (2024). Pre-and Post-Treatment Quality of Life Among Patients with Advanced Stage Cervical Cancer at Tikur Anbessa Specialized Hospital, Ethiopia. Cancer Management and Research, 16, 311–323. https://doi.org/10.2147/CMAR.S451124
Wang, H. Z., He, R. J., Zhuang, X. R., Xue, Y. W., & Lu, Y. (2022). Assessment of long-term sexual function of cervical cancer survivors after treatment: A cross-sectional study. Journal of Obstetrics and Gynaecology Research, 48(11), 2888–2895. https://doi.org/10.1111/jog.15406
Wang, S., Wen, H., Gao, Y., Lv, Q., Cao, T., Wang, S., Wang, J., Li, Y., Wang, H., Wang, Z., Sun, X., & Wang, J. (2021). Assessment of Pelvic Floor Function and Quality of Life in Patients Treated for Cervical Cancer: A Multicenter Retrospective Study. Gynecologic and Obstetric Investigation, 86(4), 353–360. https://doi.org/10.1159/000517995
WHO. (2024a). Cervical Cancer. https://www.who.int/news-room/fact-sheets/detail/cervical-cancer
WHO. (2024b). Wave of new commitments marks historic step towards the elimination of cervical cancer. https://www.who.int/news/item/05-03-2024-wave-of-new-commitments-marks-historic-step-towards-the-elimination-of-cervical-cancer
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Santi Susanti, Yanti Hermayanti, Ida Maryati

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish their manuscripts in this journal agree to the following conditions:
- The copyright on each article belongs to the author(s).
- The author acknowledges that the International Journal of Psycology and Healt Science (IJPHS) has the right to be the first to publish with a Creative Commons Attribution 4.0 International license (Attribution 4.0 International (CC BY 4.0).
- Authors can submit articles separately, arrange for the non-exclusive distribution of manuscripts that have been published in this journal into other versions (e.g., sent to the author's institutional repository, publication into books, etc.), by acknowledging that the manuscript has been published for the first time in the IJPHS.





















