Characteristics of Pap Smear Cytology Using LBC in Gynecological Patients at Siloam West Jakarta from 2023 to 2025

Authors

  • Talitha Athayarahma Tarumanagara University, Jakarta, Indonesia
  • Welly Hartono Ruslim Tarumanagara University, Jakarta, Indonesia

DOI:

https://doi.org/10.38035/ijphs.v4i2.2039

Keywords:

Cervical cancer, Liquid-Based Cytology, Pap smear, HPV infection, Bethesda system

Abstract

 Cervical cancer remains a major public health problem worldwide, particularly in developing countries, including Indonesia. Early detection through screening plays a crucial role in reducing morbidity and mortality. This study aimed to describe the cytological findings of Pap smears using the Liquid-Based Cytology (LBC) method based on the Bethesda system, as well as to analyze patient characteristics and HPV infection status among gynecological patients at Siloam West Jakarta Hospital from 2023 to 2025. This research employed a descriptive retrospective design using secondary data from the medical records of 823 patients. The variables analyzed included age, hormonal status, parity, clinical symptoms, cytology results, and HPV infection status. The results showed that most patients were aged 30–49 years and in the reproductive hormonal phase. The majority of cytological findings were categorized as Negative for Intraepithelial Lesion or Malignancy (NILM), with smaller proportion showing epithelial cell abnormalities, predominantly Atypical Squamous Cells of Undetermined Significance (ASC-US). HPV infection was detected in a minority of patients. The findings indicate that LBC is effective in identifying cervical cytology profiles and supporting early detection programs. Strengthening screening programs, particularly in high-risk populations, is essential to improve early diagnosis and prevention of cervical cancer.

References

Alrefai, E. A., Alhejaili, R. T., & Haddad, S. A. (2024). Human Papillomavirus and Its Association With Cervical Cancer: A Review. Cureus, 16(4), e57432. https://doi.org/10.7759/cureus.57432

Andola, S. K., Andola, U. S., Andola, S. S., Antony, A. T., Masgal, M., Patil, A. G., & Andola, K. S. (2024). Should Liquid-Based Cytology (LBC) be Preferred than Conventional Pap Smear (CPS): A Comparative Analysis. Journal of Obstetrics and Gynaecology of India, 74(4), 311–318. https://doi.org/10.1007/s13224-023-01828-x

Arrivillaga, M., Bermúdez, P. C., García-Cifuentes, J. P., Rodríguez-López, M., Neira, D., & Vargas-Cardona, H. D. (2023). Women’s critical experiences with the pap smear for the development of cervical cancer screening devices. Heliyon, 9(3), e14289. https://doi.org/https://doi.org/10.1016/j.heliyon.2023.e14289

Campaner, A. B., & Fernandes, G. L. (2024). Discussion on cervical cytology in postmenopausal women. Minerva Obstetrics and Gynecology, 76(6), 532–539. https://doi.org/10.23736/S2724-606X.23.05365-4

Ekaterina, K., Irakli, K., Elene, K., Ana, M., & Mariam, A. (2025). A Comparative Study of Conventional Pap Smear and Liquid-Based Cytology. Health Science Reports, 8(4), e70768. https://doi.org/10.1002/hsr2.70768

Firde, K., Zenezan, D., Afolayan-Oloye, O., & Akhtar, I. (2025). Is HPV Testing Alone or in Combination with Cytology Better? Journal of the American Society of Cytopathology, 14(5), S41–S42. https://doi.org/https://doi.org/10.1016/j.jasc.2025.07.067

Garg, R., Gandhi, G., Dhiman, N., & Agarwal, K. (2023). #559 Comparison of diagnostic efficacy of liquid based cytology (LBC) and the conventional pap smear – a prospective Indian study. International Journal of Gynecological Cancer, 33, A346. https://doi.org/10.1136/ijgc-2023-ESGO.730

Gujjar, D., Patel, D., Parikh, D., Gangwani, D., Kargathara, D., & Goswami, D. (2024). Cytopathological pattern of cervical pap smears at tertiary care hospital in year 2023. International Journal of Clinical and Diagnostic Pathology, 7, 11–16. https://doi.org/10.33545/pathol.2024.v7.i4a.2025

Han, T., & Deng, S. (2025). Prevalence and genotype distribution of Human Papillomavirus (HPV) among 14,110 women in Anqing urban area: A population-based cross-sectional survey. PloS One, 20(12), e0336959. https://doi.org/10.1371/journal.pone.0336959

Hussain, E., Mahanta, L. B., Borah, H., & Das, C. R. (2020). Liquid based-cytology Pap smear dataset for automated multi-class diagnosis of pre-cancerous and cervical cancer lesions. Data in Brief, 30, 105589. https://doi.org/https://doi.org/10.1016/j.dib.2020.105589

Kiamba, E. W., Goodier, M. R., & Clarke, E. (2025). Immune responses to human papillomavirus infection and vaccination. Frontiers in Immunology, 16, 1591297. https://doi.org/10.3389/fimmu.2025.1591297

Kumiega, N., & Madrigal, E. (2023). Digitizing Conventional Pap Smear Education: An Interactive Web-Based Open-access Tool. Journal of the American Society of Cytopathology, 12(5), S75–S76. https://doi.org/https://doi.org/10.1016/j.jasc.2023.07.139

Kuzucular, E., Ozden, F., & Muezzinoglu, B. (2024). Comparison of liquid-based cytology and cell blocks prepared from cell remnants for diagnosis of cervical pathology. Annals of Diagnostic Pathology, 69, 152265. https://doi.org/https://doi.org/10.1016/j.anndiagpath.2024.152265

Lyetunde, B. M., Salibi, G., & Tzenios, N. (2025). Special journal of the Medical Academy and other Life Sciences Impact of climate change on public health. Special Journal of The Medical Academy and Other Life Sciences, 3(6), 4–5.

Miachieo, N., Yepthomi, N., Vise, E., Jamir, B., Momin, R., & Jimo, K. (2022). Cervical cancer screening using liquid-based cytology (LBC) in a secondary care hospital in Northeast India. Indian Journal of Pathology and Oncology, 9(1), 21–24. https://doi.org/10.18231/j.ijpo.2022.005

Mishra, R., Bisht, D., & Gupta, M. (2022). Primary screening of cervical cancer by Pap smear in women of reproductive age group. Journal of Family Medicine and Primary Care, 11(9), 5327–5331. https://doi.org/10.4103/jfmpc.jfmpc_68_22

Nene, S., Dutta, I., & Kundu, M. (2025). Sociodemographic, Reproductive, and Clinical Profile of Patients With an Unhealthy Cervix: An Observational Study. Cureus, 17(12), e100298. https://doi.org/10.7759/cureus.100298

Seftianti, U., Rachmawati, M., & Sabirin, M. (2026). Hubungan Paritas dengan Hasil Pap Smear di Lab Medis Biopath Bandung. Bandung Conference Series: Medical Science, 6, 1227–1234. https://doi.org/10.29313/bcsms.v6i1.22534

Sethy, M. R., Nigam, J. S., Rath, A., Sharma, A., Prabhala, S., & Pradeep, I. (2023). Spectrum of cervicovaginal Pap smears in newly established tertiary care medical institute. CytoJournal, 20, 20. https://doi.org/10.25259/Cytojournal_8_2023

Shiga, T., Taguchi, A., Mori, M., Yamaguchi, S., Honjoh, H., Nishijima, A., Eguchi, S., Miyamoto, Y., Sone, K., Kawana, K., & Osuga, Y. (2023). Risk stratification of invasive cervical cancer diagnosed after cervical conization. Japanese Journal of Clinical Oncology, 53(12), 1138–1143. https://doi.org/10.1093/jjco/hyad121

Tahboub, R., Sanchez-Ortiz, J., Lai, M., Clark, J. L., & Zou, T. (2024). Something old, something new: Cervical cytopathology in the new era. Human Pathology Reports, 37, 300756. https://doi.org/https://doi.org/10.1016/j.hpr.2024.300756

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Published

2026-05-22